ACROMEGALY
This is Megan.Holding on to what matters.Not thinking about her acromegaly
Meet PALSONIFY. A once-daily oral medication for acromegaly.
PALSONIFY is a prescription medicine used to treat adults with acromegaly for whom surgery was not effective or surgery is not an option.
Megan, fitness enthusiast,
living with acromegaly
Who is PALSONIFY for?
PALSONIFY is proven to help maintain control of symptoms and IGF-1 levels for a range of people with acromegaly.
People who want to change medications
Ready for a change? PALSONIFY may help—even if injections weren’t right for you.
People who have discontinued medication
Previous medication didn’t work for you? PALSONIFY is different.
People new to treatment
Just diagnosed but not right for surgery? Or had surgery but still not fully controlled? Start with PALSONIFY.
IGF-1=insulin-like growth factor 1.
Designed to treat acromegaly all day
PALSONIFY is specifically made to be a once-daily oral treatment that’s absorbed efficiently through your digestive system—unlike injections. It’s designed to stay active in your body for over 24 hours, which helps maintain a steady level of medicine throughout the day with just one daily dose.
Powerful yet predictable, PALSONIFY is proven to:
Lower and maintain IGF-1 levels*
Normalize IGF-1 in 2 to 4 weeks*
Reduce symptoms of acromegaly†
*In a 24-week study of 111 people with acromegaly who were new to medication or restarting after a break, 56% of those taking PALSONIFY reached normal IGF-1 levels compared with 5% taking placebo. The majority of people who achieved IGF-1 normalization did so within the first 2 to 4 weeks. In a 36-week study of 58 people switching from injections, 83% of those taking PALSONIFY maintained normal IGF-1 levels compared with 4% taking placebo.
†In both studies, people taking PALSONIFY experienced a reduction in the severity of common acromegaly symptoms.
The most common PALSONIFY side effects for people switching from injections were diarrhea (23%), nausea (13%), loss of appetite (10%), irregular heartbeat (palpitations) (7%), and stomach bug–like symptoms (gastroenteritis) (7%). The most common PALSONIFY side effects for people new to or restarting medication were diarrhea (33%), stomach pain or discomfort (19%), nausea (9%), slow heart rate (bradycardia) (7%), and high blood sugar (7%).
Start PALSONIFY with support
CrinetiCARE provides personalized support to help you navigate your treatment journey with PALSONIFY.
Whether you have questions about insurance coverage, need help finding a healthcare provider, or are seeking a nurse educator, CrinetiCARE is here to help.
What is PALSONIFY?
- PALSONIFY is a prescription medicine used to treat adults with acromegaly for whom surgery was not effective or surgery is not an option
- It is not known if PALSONIFY is safe and effective in children
IMPORTANT SAFETY INFORMATION
What should I tell my healthcare provider before taking PALSONIFY?
Before taking PALSONIFY, tell your healthcare provider about all your medical conditions, including if you:
- have gallbladder problems
- have blood sugar control problems (low blood sugar or high blood sugar)
- have problems with low heart rate
- are pregnant or plan to become pregnant. It is not known if PALSONIFY will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if PALSONIFY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take PALSONIFY.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PALSONIFY may affect the way other medicines work, and other medicines may affect how PALSONIFY works.
Especially tell your healthcare provider if you take any medicines that can slow the heart rate.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
What are the possible side effects of PALSONIFY?
PALSONIFY may cause serious side effects including:
- Gallbladder problems: PALSONIFY may cause problems with the gallbladder. Tell your healthcare provider if you have sudden pain in the upper right area of your stomach (abdomen), sudden pain in your right shoulder or between your shoulder blades, yellowing of your skin or the whites of your eyes, or pale stools.
- Blood sugar problems: PALSONIFY may change hormone levels, potentially causing either high blood sugar (hyperglycemia), including diabetes, or low blood sugar (hypoglycemia). Tell your healthcare provider if you have problems with high or low blood sugar. Your healthcare provider will check your blood sugar when you start taking PALSONIFY or when your dose is changed.
- Heart rate problems: Tell your healthcare provider if your heart is not beating normally.
- Thyroid problems: PALSONIFY may keep your thyroid from releasing thyroid hormones, leading to hypothyroidism. Your thyroid function may be checked periodically during your treatment with PALSONIFY.
- Fatty stools: PALSONIFY may cause your body to have problems with absorbing dietary fats. Tell your healthcare provider if you have any new or worsening symptoms, including fatty stools, changes in the color of your stools, loose stools, stomach (abdominal) bloating, or weight loss.
- Low vitamin B12 levels in your blood: Your healthcare provider may check your vitamin B12 levels during treatment with PALSONIFY.
The most common side effects of PALSONIFY include diarrhea, pain in your stomach (abdominal) area, nausea and vomiting, decreased appetite, slow heart rate (bradycardia), high blood sugar levels (hyperglycemia), and irregular heartbeat (palpitations).
These are not all the possible side effects of PALSONIFY. For more information, ask your healthcare provider or pharmacist.
You are encouraged to report negative side effects to Crinetics Pharmaceuticals at 1-833-CRN-INFO (1-833-276-4636) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Please see Full Prescribing Information, including Patient Information, and talk to your doctor.
What is PALSONIFY?
- PALSONIFY is a prescription medicine used to treat adults with acromegaly for whom surgery was not effective or surgery is not an option
- It is not known if PALSONIFY is safe and effective in children
IMPORTANT SAFETY INFORMATION
What should I tell my healthcare provider before taking PALSONIFY?
Before taking PALSONIFY, tell your healthcare provider about all your medical conditions, including if you:
- have gallbladder problems
- have blood sugar control problems (low blood sugar or high blood sugar)
- have problems with low heart rate
- are pregnant or plan to become pregnant. It is not known if PALSONIFY will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if PALSONIFY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take PALSONIFY.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PALSONIFY may affect the way other medicines work, and other medicines may affect how PALSONIFY works.
Especially tell your healthcare provider if you take any medicines that can slow the heart rate.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
What are the possible side effects of PALSONIFY?
PALSONIFY may cause serious side effects including:
- Gallbladder problems: PALSONIFY may cause problems with the gallbladder. Tell your healthcare provider if you have sudden pain in the upper right area of your stomach (abdomen), sudden pain in your right shoulder or between your shoulder blades, yellowing of your skin or the whites of your eyes, or pale stools.
- Blood sugar problems: PALSONIFY may change hormone levels, potentially causing either high blood sugar (hyperglycemia), including diabetes, or low blood sugar (hypoglycemia). Tell your healthcare provider if you have problems with high or low blood sugar. Your healthcare provider will check your blood sugar when you start taking PALSONIFY or when your dose is changed.
- Heart rate problems: Tell your healthcare provider if your heart is not beating normally.
- Thyroid problems: PALSONIFY may keep your thyroid from releasing thyroid hormones, leading to hypothyroidism. Your thyroid function may be checked periodically during your treatment with PALSONIFY.
- Fatty stools: PALSONIFY may cause your body to have problems with absorbing dietary fats. Tell your healthcare provider if you have any new or worsening symptoms, including fatty stools, changes in the color of your stools, loose stools, stomach (abdominal) bloating, or weight loss.
- Low vitamin B12 levels in your blood: Your healthcare provider may check your vitamin B12 levels during treatment with PALSONIFY.
The most common side effects of PALSONIFY include diarrhea, pain in your stomach (abdominal) area, nausea and vomiting, decreased appetite, slow heart rate (bradycardia), high blood sugar levels (hyperglycemia), and irregular heartbeat (palpitations).
These are not all the possible side effects of PALSONIFY. For more information, ask your healthcare provider or pharmacist.
You are encouraged to report negative side effects to Crinetics Pharmaceuticals at 1-833-CRN-INFO (1-833-276-4636) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Please see Full Prescribing Information, including Patient Information, and talk to your doctor.
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©2025 Crinetics Pharmaceuticals, Inc. PALSONIFY is a trademark and CrinetiCARE is a registered trademark of Crinetics Pharmaceuticals, Inc. All rights reserved.
US-PAL-2500063-1 11/2025
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