For bipolar I depression in adults and for treatment of short-term manic or mixed episodes of bipolar I disorder in adults and children ages 10 years and older.

Bipolar I Basics

What is bipolar I disorder?

Bipolar I disorder is a condition that causes periods of severe changes in your mood, activity levels, energy, and ability to carry out everyday tasks. These changes are commonly called “mood episodes.”

Although you may feel alone, ~3 million Americans are affected by bipolar I disorder each year
While anyone can develop bipolar I disorder, it often starts in the late teen or early adult years and it lasts a lifetime
Medical researchers believe that it can result from many factors, including an imbalance of certain chemicals in the brain called neurotransmitters, which may be too high or too low

Did you know?

Bipolar I disorder often runs in families. If you have a family history of bipolar I disorder, be sure to let your healthcare provider know.

Have you taken any medication(s) for your bipolar I?

Select an answer below to learn how VRAYLAR may work to treat your bipolar I.Yes, I have taken multiple medications to help treat my bipolar I.Yes, I have taken one medication to treat my bipolar I.No, but I would like to learn more about managing bipolar I.

What are the symptoms of bipolar I?

Bipolar I disorder can cause unpredictable high and low mood swings, also known as manic and depressive episodes.

Bex and Heidi, two individuals living with bipolar I, shed light on depressive and manic aspects of bipolar I.

The people featured in these videos are sharing their individual experiences with bipolar I. Individual experiences with the condition and treatment will vary. Not all of those featured are currently taking VRAYLAR. These videos are brought to you by AbbVie.Play Video

Bex’s experience with bipolar I depression

View transcriptPlay Video

Heidi’s experience with bipolar I mania

View transcript

Symptoms to consider talking to your healthcare provider about

Select a mood state below to see common symptoms.
Not all of these symptoms may be indicative of bipolar I.

Depressive symptoms

Mixed episodes

Manic symptoms

Commonly referred to as the “lows,” depressive symptoms include at least five of the following, lasting for at least two weeks:

Having trouble concentrating
Forgetting things a lot
Thinking about death or suicide
Having trouble sleeping
Feeling like you can’t enjoy anything
Feeling very down or sad
Feeling worried and empty
Sleeping too much or too little
Changes in appetite or weight
Having little to no interest or pleasure in your hobbies

Do these symptoms sound familiar?

Answer some questions that could help your healthcare provider determine whether you may have bipolar I disorder.

Take quiz

What can trigger bipolar I episodes?

Depressive and manic episodes are often triggered by something. Being aware of your triggers or warning signs can help you in managing your mood episodes.

Common triggers for bipolar I disorder may include:

Sleep deprivation
Medications
Seasonal changes
Substance abuse

Some triggers you can control or manage, while others you may not. Be sure to discuss your triggers with your doctor.

Use this mood tracker to record your symptoms each day and help your healthcare provider spot warning signs of bipolar I disorder.

Track your mood

Approaches to managing bipolar I disorder video thumbnail.

Watch Now

Tips on ways you can manage bipolar I disorder

View Transcript

How is bipolar I disorder diagnosed?

Bipolar I disorder can go unrecognized for years by not only those who suffer with it, but by family, friends, and even healthcare providers. Manic symptoms are reported less often than depressive ones for most people with bipolar I, so healthcare providers may only see, and therefore treat, symptoms of depression instead of bipolar I disorder.

The first step: If you think you or your loved one may have bipolar I disorder, talk with a doctor. They can complete a physical exam to rule out other conditions.

Why this matters: People with bipolar disorder often have other health problems including substance abuse, anxiety disorders, thyroid disease, heart disease, and obesity. These conditions can have similar symptoms to bipolar I disorder, which can complicate the diagnosis of bipolar I disorder.

Bipolar I depression is different

Bipolar refers to the opposite ends (the poles) of the emotional spectrum—lows (depression) and the highs (mania). In addition to the deep, unshakeable sadness or emptiness felt by patients with major depressive disorder (MDD), patients with bipolar I also experience manic episodes.

Treatments for MDD may not be effective for patients with bipolar I disorder, so it’s important to get the right diagnosis.

Learn about VRAYLAR

How is bipolar I treated?

An effective treatment plan for bipolar I often includes a combination of:

Medication

Talk therapy

Support groups

Improving overall health and wellness

However, the cornerstone of every treatment plan is medication, and finding the right one can take some time.

Your healthcare provider will start the process by evaluating your symptoms and treatments. So it’s critical to share all the symptoms you’re experiencing now or have experienced in the past, as well as the medications you’re taking now or have taken in the past.

Make the most out of your appointment

Help your provider understand how you’re feeling. Complete this simple quiz about your symptoms to create a personalized discussion guide for your next appointment.

Take quiz

Additional resources

Tips for managing bipolar I

Discover tips that may help manage your bipolar I disorder.

Download brochure

Bipolar I quiz

Answer questions that could help your healthcare provider determine whether you may have bipolar I disorder.

Take quiz

Bipolar I support

Get updates

*Terms and conditions apply. Available to commercially insured patients only. See Terms and Conditions for full details.

INDICATIONS AND USAGE

VRAYLAR is a prescription medicine used to treat depressive episodes that happen with bipolar I disorder (bipolar depression) in adults and to treat short-term (acute) manic or mixed episodes that happen with bipolar I disorder in adults and children ages 10 years and older.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about VRAYLAR?

Elderly people with dementia-related psychosis (having lost touch with reality due to confusion and memory loss) taking medicines like VRAYLAR are at an increased risk of death. VRAYLAR is not approved for treating patients with dementia-related psychosis.

VRAYLAR and antidepressants increase the risk of suicidal thoughts or actions in people 24 years of age and younger especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions. Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when VRAYLAR or the antidepressant is started or when the dose is changed. Report any change in these symptoms immediately to the doctor.

VRAYLAR may cause serious side effects, including:

Stroke (cerebrovascular problems) in elderly people with dementia-related psychosis that can lead to death
Neuroleptic malignant syndrome (NMS): Call your healthcare provider or go to the nearest hospital emergency room right away if you have high fever, stiff muscles, confusion, increased sweating, or changes in breathing, heart rate, and blood pressure. These can be symptoms of a rare but potentially fatal side effect called NMS. VRAYLAR should be stopped if you have NMS.
Uncontrolled body movements (tardive dyskinesia or TD): VRAYLAR may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking VRAYLAR. Tardive dyskinesia may also start after you stop taking VRAYLAR.
Late-occurring side effects: VRAYLAR stays in your body for a long time. Some side effects may not happen right away and can start a few weeks after starting VRAYLAR, or if your dose increases. Your healthcare provider should monitor you for side effects for several weeks after starting or increasing dose of VRAYLAR.
Problems with your metabolism, such as:
- High blood sugar and diabetes: Increases in blood sugar can happen in some people who take VRAYLAR. Extremely high blood sugar can lead to coma or death. Your healthcare provider should check your blood sugar before or soon after starting VRAYLAR and regularly during treatment. Tell your healthcare provider if you have symptoms such as feeling very thirsty, very hungry, or sick to your stomach, urinating more than usual, feeling weak, tired, confused, or your breath smells fruity.
- Increased fat levels (cholesterol and triglycerides) in your blood: Your healthcare provider should check fat levels in your blood before or soon after starting VRAYLAR and during treatment.
- Weight gain: Weight gain has been reported with VRAYLAR. You and your healthcare provider should check your weight before and regularly during treatment.
Low white blood cell count: Low white blood cell counts have been reported with antipsychotic drugs, including VRAYLAR. This may increase your risk of infection. Very low white blood cell counts, which can be fatal, have been reported with other antipsychotics. Your healthcare provider may do blood tests during the first few months of treatment with VRAYLAR.
Decreased blood pressure (orthostatic hypotension): You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
Falls: VRAYLAR may make you sleepy or dizzy, may cause a decrease in blood pressure when changing position (orthostatic hypotension), and can slow thinking and motor skills, which may lead to falls that can cause fractures or other injuries.
Seizures (convulsions)
Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities: Do NOT drive, operate machinery, or do other dangerous activities until you know how VRAYLAR affects you. VRAYLAR may make you drowsy.
Increased body temperature: Do not become too hot or dehydrated during VRAYLAR treatment. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
Difficulty swallowing that can cause food or liquid to get into your lungs

Who should not take VRAYLAR?

Do not take VRAYLAR if you are allergic to any of its ingredients. Get emergency medical help if you are having an allergic reaction (eg, rash, itching, hives, swelling of the tongue, lip, face or throat).

What should I tell my healthcare provider before taking VRAYLAR?

Tell your healthcare provider about any medical conditions and if you:

have or had heart problems or a stroke
have or had low or high blood pressure
have or had diabetes or high blood sugar in you or your family
have or had high levels of total cholesterol, LDL-cholesterol, or triglycerides; or low levels of HDL-cholesterol
have or had seizures (convulsions)
have or had kidney or liver problems
have or had low white blood cell count
are pregnant or plan to become pregnant. VRAYLAR may harm your unborn baby. Taking VRAYLAR during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take VRAYLAR during pregnancy. There is a pregnancy exposure registry for women who are exposed to VRAYLAR during pregnancy. If you become pregnant or think you are pregnant during treatment, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388 or http://www.womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.
are breastfeeding or plan to breastfeed. It is not known if VRAYLAR passes into breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with VRAYLAR.

Tell your healthcare provider about all medicines that you take, including prescriptions, over-the-counter medicines, vitamins, and supplements. VRAYLAR may affect the way other medicines work, and other medicines may affect how VRAYLAR works. Do not start or stop any medicines while taking VRAYLAR without talking to your healthcare provider.

What are the most common side effects of VRAYLAR?

The most common side effects include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, indigestion, constipation, feeling tired, trouble sleeping, increased appetite, and dizziness.

These are not all the possible side effects of VRAYLAR.

VRAYLAR is available in 0.5 mg, 0.75 mg, 1.5 mg, 3 mg, 4.5 mg, and 6 mg capsules.

INDICATIONS AND USAGE

VRAYLAR is a prescription medicine used:

along with antidepressant medicines to treat major depressive disorder (MDD) in adults
to treat depressive episodes that happen with bipolar I disorder (bipolar depression) in adults
to treat short-term (acute) manic or mixed episodes that happen with bipolar I disorder in adults and children ages 10 years and older

Please see the full Prescribing Information, including Boxed Warnings, and Medication Guide.

US-VRAA-250457

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

THIS SITE IS INTENDED FOR U.S. CONSUMERS ONLY.

LICENSED FROM GEDEON RICHTER PLC.
© 2026 ABBVIE. ALL RIGHTS RESERVED.

VRAYLAR^® AND ITS DESIGN ARE TRADEMARKS OF ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED, AN ABBVIE COMPANY.

IF YOU ARE A PATIENT, AND HAVE ANY QUESTIONS, PLEASE DISCUSS THEM WITH YOUR DOCTOR OR HEALTHCARE PROVIDER.

FOR ADDITIONAL INFORMATION ABOUT VRAYLAR^®, CALL ABBVIE MEDICAL INFORMATION TOLL-FREE AT 1.800.678.1605.

US-VRA-250393

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about VRAYLAR?

For bipolar I depression in adults and for treatment of short-term manic or mixed episodes of bipolar I disorder in adults and children ages 10 years and older.

Bipolar I Basics

What is bipolar I disorder?

Although you may feel alone, ~3 million Americans are affected by bipolar I disorder each year
While anyone can develop bipolar I disorder, it often starts in the late teen or early adult years and it lasts a lifetime
Medical researchers believe that it can result from many factors, including an imbalance of certain chemicals in the brain called neurotransmitters, which may be too high or too low

Did you know?

Bipolar I disorder often runs in families. If you have a family history of bipolar I disorder, be sure to let your healthcare provider know.

Have you taken any medication(s) for your bipolar I?

What are the symptoms of bipolar I?

Bipolar I disorder can cause unpredictable high and low mood swings, also known as manic and depressive episodes.

Bex and Heidi, two individuals living with bipolar I, shed light on depressive and manic aspects of bipolar I.

Bex’s experience with bipolar I depression

View transcriptPlay Video

Heidi’s experience with bipolar I mania

View transcript

Symptoms to consider talking to your healthcare provider about

Select a mood state below to see common symptoms.
Not all of these symptoms may be indicative of bipolar I.

Depressive symptoms

Mixed episodes

Manic symptoms

Commonly referred to as the “lows,” depressive symptoms include at least five of the following, lasting for at least two weeks:

Having trouble concentrating
Forgetting things a lot
Thinking about death or suicide
Having trouble sleeping
Feeling like you can’t enjoy anything
Feeling very down or sad
Feeling worried and empty
Sleeping too much or too little
Changes in appetite or weight
Having little to no interest or pleasure in your hobbies

Do these symptoms sound familiar?

Answer some questions that could help your healthcare provider determine whether you may have bipolar I disorder.

Take quiz

What can trigger bipolar I episodes?

Depressive and manic episodes are often triggered by something. Being aware of your triggers or warning signs can help you in managing your mood episodes.

Common triggers for bipolar I disorder may include:

Sleep deprivation
Medications
Seasonal changes
Substance abuse

Some triggers you can control or manage, while others you may not. Be sure to discuss your triggers with your doctor.

Use this mood tracker to record your symptoms each day and help your healthcare provider spot warning signs of bipolar I disorder.

Track your mood

Watch Now

Tips on ways you can manage bipolar I disorder

View Transcript

How is bipolar I disorder diagnosed?

The first step: If you think you or your loved one may have bipolar I disorder, talk with a doctor. They can complete a physical exam to rule out other conditions.

Bipolar I depression is different

Treatments for MDD may not be effective for patients with bipolar I disorder, so it’s important to get the right diagnosis.

Learn about VRAYLAR

How is bipolar I treated?

An effective treatment plan for bipolar I often includes a combination of:

Medication

Talk therapy

Support groups

Improving overall health and wellness

However, the cornerstone of every treatment plan is medication, and finding the right one can take some time.

Make the most out of your appointment

Help your provider understand how you’re feeling. Complete this simple quiz about your symptoms to create a personalized discussion guide for your next appointment.

Take quiz

Additional resources

Tips for managing bipolar I

Discover tips that may help manage your bipolar I disorder.

Download brochure

Bipolar I quiz

Answer questions that could help your healthcare provider determine whether you may have bipolar I disorder.

Take quiz

Bipolar I support

Get updates

*Terms and conditions apply. Available to commercially insured patients only. See Terms and Conditions for full details.

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about VRAYLAR?

VRAYLAR may cause serious side effects, including:

Stroke (cerebrovascular problems) in elderly people with dementia-related psychosis that can lead to death
Neuroleptic malignant syndrome (NMS): Call your healthcare provider or go to the nearest hospital emergency room right away if you have high fever, stiff muscles, confusion, increased sweating, or changes in breathing, heart rate, and blood pressure. These can be symptoms of a rare but potentially fatal side effect called NMS. VRAYLAR should be stopped if you have NMS.
Uncontrolled body movements (tardive dyskinesia or TD): VRAYLAR may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking VRAYLAR. Tardive dyskinesia may also start after you stop taking VRAYLAR.
Late-occurring side effects: VRAYLAR stays in your body for a long time. Some side effects may not happen right away and can start a few weeks after starting VRAYLAR, or if your dose increases. Your healthcare provider should monitor you for side effects for several weeks after starting or increasing dose of VRAYLAR.
Problems with your metabolism, such as:
- High blood sugar and diabetes: Increases in blood sugar can happen in some people who take VRAYLAR. Extremely high blood sugar can lead to coma or death. Your healthcare provider should check your blood sugar before or soon after starting VRAYLAR and regularly during treatment. Tell your healthcare provider if you have symptoms such as feeling very thirsty, very hungry, or sick to your stomach, urinating more than usual, feeling weak, tired, confused, or your breath smells fruity.
- Increased fat levels (cholesterol and triglycerides) in your blood: Your healthcare provider should check fat levels in your blood before or soon after starting VRAYLAR and during treatment.
- Weight gain: Weight gain has been reported with VRAYLAR. You and your healthcare provider should check your weight before and regularly during treatment.
Low white blood cell count: Low white blood cell counts have been reported with antipsychotic drugs, including VRAYLAR. This may increase your risk of infection. Very low white blood cell counts, which can be fatal, have been reported with other antipsychotics. Your healthcare provider may do blood tests during the first few months of treatment with VRAYLAR.
Decreased blood pressure (orthostatic hypotension): You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
Falls: VRAYLAR may make you sleepy or dizzy, may cause a decrease in blood pressure when changing position (orthostatic hypotension), and can slow thinking and motor skills, which may lead to falls that can cause fractures or other injuries.
Seizures (convulsions)
Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities: Do NOT drive, operate machinery, or do other dangerous activities until you know how VRAYLAR affects you. VRAYLAR may make you drowsy.
Increased body temperature: Do not become too hot or dehydrated during VRAYLAR treatment. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
Difficulty swallowing that can cause food or liquid to get into your lungs

Who should not take VRAYLAR?

What should I tell my healthcare provider before taking VRAYLAR?

Tell your healthcare provider about any medical conditions and if you:

have or had heart problems or a stroke
have or had low or high blood pressure
have or had diabetes or high blood sugar in you or your family
have or had high levels of total cholesterol, LDL-cholesterol, or triglycerides; or low levels of HDL-cholesterol
have or had seizures (convulsions)
have or had kidney or liver problems
have or had low white blood cell count
are pregnant or plan to become pregnant. VRAYLAR may harm your unborn baby. Taking VRAYLAR during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take VRAYLAR during pregnancy. There is a pregnancy exposure registry for women who are exposed to VRAYLAR during pregnancy. If you become pregnant or think you are pregnant during treatment, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388 or http://www.womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.
are breastfeeding or plan to breastfeed. It is not known if VRAYLAR passes into breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with VRAYLAR.

What are the most common side effects of VRAYLAR?

The most common side effects include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, indigestion, constipation, feeling tired, trouble sleeping, increased appetite, and dizziness.

These are not all the possible side effects of VRAYLAR.

VRAYLAR is available in 0.5 mg, 0.75 mg, 1.5 mg, 3 mg, 4.5 mg, and 6 mg capsules.

INDICATIONS AND USAGE

VRAYLAR is a prescription medicine used:

along with antidepressant medicines to treat major depressive disorder (MDD) in adults
to treat depressive episodes that happen with bipolar I disorder (bipolar depression) in adults
to treat short-term (acute) manic or mixed episodes that happen with bipolar I disorder in adults and children ages 10 years and older

Please see the full Prescribing Information, including Boxed Warnings, and Medication Guide.

US-VRAA-250457

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

THIS SITE IS INTENDED FOR U.S. CONSUMERS ONLY.

LICENSED FROM GEDEON RICHTER PLC.
© 2026 ABBVIE. ALL RIGHTS RESERVED.

VRAYLAR^® AND ITS DESIGN ARE TRADEMARKS OF ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED, AN ABBVIE COMPANY.

IF YOU ARE A PATIENT, AND HAVE ANY QUESTIONS, PLEASE DISCUSS THEM WITH YOUR DOCTOR OR HEALTHCARE PROVIDER.

FOR ADDITIONAL INFORMATION ABOUT VRAYLAR^®, CALL ABBVIE MEDICAL INFORMATION TOLL-FREE AT 1.800.678.1605.

US-VRA-250393

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about VRAYLAR?

For bipolar I depression in adults and for treatment of short-term manic or mixed episodes of bipolar I disorder in adults and children ages 10 years and older.

Bipolar I Basics

What is bipolar I disorder?

Although you may feel alone, ~3 million Americans are affected by bipolar I disorder each year
While anyone can develop bipolar I disorder, it often starts in the late teen or early adult years and it lasts a lifetime
Medical researchers believe that it can result from many factors, including an imbalance of certain chemicals in the brain called neurotransmitters, which may be too high or too low

Did you know?

Bipolar I disorder often runs in families. If you have a family history of bipolar I disorder, be sure to let your healthcare provider know.

Have you taken any medication(s) for your bipolar I?

What are the symptoms of bipolar I?

Bipolar I disorder can cause unpredictable high and low mood swings, also known as manic and depressive episodes.

Bex and Heidi, two individuals living with bipolar I, shed light on depressive and manic aspects of bipolar I.

Bex’s experience with bipolar I depression

View transcriptPlay Video

Heidi’s experience with bipolar I mania

View transcript

Symptoms to consider talking to your healthcare provider about

Select a mood state below to see common symptoms.
Not all of these symptoms may be indicative of bipolar I.

Depressive symptoms

Mixed episodes

Manic symptoms

Commonly referred to as the “lows,” depressive symptoms include at least five of the following, lasting for at least two weeks:

Having trouble concentrating
Forgetting things a lot
Thinking about death or suicide
Having trouble sleeping
Feeling like you can’t enjoy anything
Feeling very down or sad
Feeling worried and empty
Sleeping too much or too little
Changes in appetite or weight
Having little to no interest or pleasure in your hobbies

Do these symptoms sound familiar?

Answer some questions that could help your healthcare provider determine whether you may have bipolar I disorder.

Take quiz

What can trigger bipolar I episodes?

Depressive and manic episodes are often triggered by something. Being aware of your triggers or warning signs can help you in managing your mood episodes.

Common triggers for bipolar I disorder may include:

Sleep deprivation
Medications
Seasonal changes
Substance abuse

Some triggers you can control or manage, while others you may not. Be sure to discuss your triggers with your doctor.

Use this mood tracker to record your symptoms each day and help your healthcare provider spot warning signs of bipolar I disorder.

Track your mood

Watch Now

Tips on ways you can manage bipolar I disorder

View Transcript

How is bipolar I disorder diagnosed?

The first step: If you think you or your loved one may have bipolar I disorder, talk with a doctor. They can complete a physical exam to rule out other conditions.

Bipolar I depression is different

Treatments for MDD may not be effective for patients with bipolar I disorder, so it’s important to get the right diagnosis.

Learn about VRAYLAR

How is bipolar I treated?

An effective treatment plan for bipolar I often includes a combination of:

Medication

Talk therapy

Support groups

Improving overall health and wellness

However, the cornerstone of every treatment plan is medication, and finding the right one can take some time.

Make the most out of your appointment

Help your provider understand how you’re feeling. Complete this simple quiz about your symptoms to create a personalized discussion guide for your next appointment.

Take quiz

Additional resources

Tips for managing bipolar I

Discover tips that may help manage your bipolar I disorder.

Download brochure

Bipolar I quiz

Answer questions that could help your healthcare provider determine whether you may have bipolar I disorder.

Take quiz

Bipolar I support

Get updates

*Terms and conditions apply. Available to commercially insured patients only. See Terms and Conditions for full details.

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about VRAYLAR?

VRAYLAR may cause serious side effects, including:

Stroke (cerebrovascular problems) in elderly people with dementia-related psychosis that can lead to death
Neuroleptic malignant syndrome (NMS): Call your healthcare provider or go to the nearest hospital emergency room right away if you have high fever, stiff muscles, confusion, increased sweating, or changes in breathing, heart rate, and blood pressure. These can be symptoms of a rare but potentially fatal side effect called NMS. VRAYLAR should be stopped if you have NMS.
Uncontrolled body movements (tardive dyskinesia or TD): VRAYLAR may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking VRAYLAR. Tardive dyskinesia may also start after you stop taking VRAYLAR.
Late-occurring side effects: VRAYLAR stays in your body for a long time. Some side effects may not happen right away and can start a few weeks after starting VRAYLAR, or if your dose increases. Your healthcare provider should monitor you for side effects for several weeks after starting or increasing dose of VRAYLAR.
Problems with your metabolism, such as:
- High blood sugar and diabetes: Increases in blood sugar can happen in some people who take VRAYLAR. Extremely high blood sugar can lead to coma or death. Your healthcare provider should check your blood sugar before or soon after starting VRAYLAR and regularly during treatment. Tell your healthcare provider if you have symptoms such as feeling very thirsty, very hungry, or sick to your stomach, urinating more than usual, feeling weak, tired, confused, or your breath smells fruity.
- Increased fat levels (cholesterol and triglycerides) in your blood: Your healthcare provider should check fat levels in your blood before or soon after starting VRAYLAR and during treatment.
- Weight gain: Weight gain has been reported with VRAYLAR. You and your healthcare provider should check your weight before and regularly during treatment.
Low white blood cell count: Low white blood cell counts have been reported with antipsychotic drugs, including VRAYLAR. This may increase your risk of infection. Very low white blood cell counts, which can be fatal, have been reported with other antipsychotics. Your healthcare provider may do blood tests during the first few months of treatment with VRAYLAR.
Decreased blood pressure (orthostatic hypotension): You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
Falls: VRAYLAR may make you sleepy or dizzy, may cause a decrease in blood pressure when changing position (orthostatic hypotension), and can slow thinking and motor skills, which may lead to falls that can cause fractures or other injuries.
Seizures (convulsions)
Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities: Do NOT drive, operate machinery, or do other dangerous activities until you know how VRAYLAR affects you. VRAYLAR may make you drowsy.
Increased body temperature: Do not become too hot or dehydrated during VRAYLAR treatment. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
Difficulty swallowing that can cause food or liquid to get into your lungs

Who should not take VRAYLAR?

What should I tell my healthcare provider before taking VRAYLAR?

Tell your healthcare provider about any medical conditions and if you:

have or had heart problems or a stroke
have or had low or high blood pressure
have or had diabetes or high blood sugar in you or your family
have or had high levels of total cholesterol, LDL-cholesterol, or triglycerides; or low levels of HDL-cholesterol
have or had seizures (convulsions)
have or had kidney or liver problems
have or had low white blood cell count
are pregnant or plan to become pregnant. VRAYLAR may harm your unborn baby. Taking VRAYLAR during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take VRAYLAR during pregnancy. There is a pregnancy exposure registry for women who are exposed to VRAYLAR during pregnancy. If you become pregnant or think you are pregnant during treatment, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388 or http://www.womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.
are breastfeeding or plan to breastfeed. It is not known if VRAYLAR passes into breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with VRAYLAR.

What are the most common side effects of VRAYLAR?

The most common side effects include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, indigestion, constipation, feeling tired, trouble sleeping, increased appetite, and dizziness.

These are not all the possible side effects of VRAYLAR.

VRAYLAR is available in 0.5 mg, 0.75 mg, 1.5 mg, 3 mg, 4.5 mg, and 6 mg capsules.

INDICATIONS AND USAGE

VRAYLAR is a prescription medicine used:

along with antidepressant medicines to treat major depressive disorder (MDD) in adults
to treat depressive episodes that happen with bipolar I disorder (bipolar depression) in adults
to treat short-term (acute) manic or mixed episodes that happen with bipolar I disorder in adults and children ages 10 years and older

Please see the full Prescribing Information, including Boxed Warnings, and Medication Guide.

US-VRAA-250457

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

THIS SITE IS INTENDED FOR U.S. CONSUMERS ONLY.

VRAYLAR^® AND ITS DESIGN ARE TRADEMARKS OF ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED, AN ABBVIE COMPANY.

IF YOU ARE A PATIENT, AND HAVE ANY QUESTIONS, PLEASE DISCUSS THEM WITH YOUR DOCTOR OR HEALTHCARE PROVIDER.

FOR ADDITIONAL INFORMATION ABOUT VRAYLAR^®, CALL ABBVIE MEDICAL INFORMATION TOLL-FREE AT 1.800.678.1605.

US-VRA-250393

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about VRAYLAR?

Bipolar I Basics

What is bipolar I disorder?

Did you know?

Have you taken any medication(s) for your bipolar I?

What are the symptoms of bipolar I?

Symptoms to consider talking to your healthcare provider about

Do these symptoms sound familiar?

What can trigger bipolar I episodes?

Common triggers for bipolar I disorder may include:

How is bipolar I disorder diagnosed?

Bipolar I depression is different

How is bipolar I treated?

Make the most out of your appointment

Additional resources

Tips for managing bipolar I

Bipolar I quiz

Bipolar I support

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

Bipolar I Basics

What is bipolar I disorder?

Did you know?

Have you taken any medication(s) for your bipolar I?

What are the symptoms of bipolar I?

Symptoms to consider talking to your healthcare provider about

Do these symptoms sound familiar?

What can trigger bipolar I episodes?

Common triggers for bipolar I disorder may include:

How is bipolar I disorder diagnosed?

Bipolar I depression is different

How is bipolar I treated?

Make the most out of your appointment

Additional resources

Tips for managing bipolar I

Bipolar I quiz

Bipolar I support

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

Bipolar I Basics

What is bipolar I disorder?

Did you know?

Have you taken any medication(s) for your bipolar I?

What are the symptoms of bipolar I?

Symptoms to consider talking to your healthcare provider about

Do these symptoms sound familiar?

What can trigger bipolar I episodes?

Common triggers for bipolar I disorder may include:

How is bipolar I disorder diagnosed?

Bipolar I depression is different

How is bipolar I treated?

Make the most out of your appointment

Additional resources

Tips for managing bipolar I

Bipolar I quiz

Bipolar I support

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

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